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Interleukin-1 is a cytokine that stimulates production of interleukin-6 by cell lines of hematopoietic origin and also has a wide variety of biologic actions. The IL-1 family consists of two subfamilies, IL-1 alpha, IL-1 beta and IL-1 gamma. There are striking similarities in the function of IL-1 family members, including induction of fever, hypotension, anorexia, thymocyte-mediated inhibition of mitogen-induced lymphocyte proliferation, stimulation of osteoclast bone resorption and promotion of endothelial cell growth. However, IL-1 alpha and IL-1 beta are unable to stimulate interleukin-6 production and to act on bone. In contrast, IL-1 alpha is able to act on endothelial cells. We have expressed mouse IL-1 alpha, IL-1 beta and IL-1 gamma in Saccharomyces cerevisiae and demonstrated that each heterodimeric cytokine retains biological activity. Unlike IL-1 beta, IL-1 alpha and IL-1 gamma stimulated an increase in the level of intracellular cAMP. IL-1 alpha also induced a wide variety of biologic responses that are characteristic of IL-1, including stimulation of interleukin-6 production, enhancement of phagocytosis, stimulation of macrophage tumor necrosis factor production and stimulation of osteoclast-mediated resorption of bone. These data show that in S. cerevisiae recombinant mouse IL-1 alpha, IL-1 beta and IL-1 gamma are capable of functioning to mediate a broad range of biologic activities.The evolution of diploid chromosome number and genome size in primates.
The karyotypes of 26 genera of primates, which include all extant families of the order, are compared. In general, the diploid chromosome number
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